Al Leslie

PI and Faculty member Africa Health Research Institute (AHRI)

My group investigates the immune response to HIV and TB infection in tissue, using locally available excess material from surgical procedures. We are particularly interested in the relationship between the immune response to these pathogens at the site of disease, and those that are detectable with in the blood. We make use of advanced flow cytometry, single cell RNA sequencing, immunofluorescent histology and 3D tissue culture to investigate the phenotype and function of tissue resident immune populations. The aim, is to uncover new biology that will aid the development of novel therapeutic interventions and improve the health of individuals afflicted with these deadly infections.